With Wales captain Dewi Lake ruled out for the first half of the Six Nations with a bicep injury and deputy hooker Ryan Elias recovering from a neck problem, Warren Gatland could scarcely afford to lose any more of his big players.
Wales take on France in their opening game on Friday, 31 January.
Elliot Dee had been due to make his first start of the campaign for Dragons after an ankle injury, but a niggle forced a late withdrawal.
Aaron Wainwright caused a few concerns when he left the field on 25 minutes with a suspected concussion, but he returned after passing his head injury assessment. Rhodri Williams also suffered a knock late on.
There were plenty of performances that would please Gatland, Jac Morgan who will likely resume captain duties in Lake’s absence, was again a stalwart for Ospreys.
Sam Parry, who left the national training squad in June in controversial circumstances, also showed his international pedigree.
Rhys Davies put in a great shift on his first appearance since March, while Dan Edwards continued to impress at 10.
Cardiff’s Teddy Williams was a nuisance in the lineout before his yellow card, while the abrasive Seb Davies also caught the eye.
Sam Costelow pulled the strings for Scarlets, Blair Murray showed his finishing prowess with two tries, while Josh Macloed led from the front.
Rio Dyer was again a bright spark in the Dragons side.
