New coronavirus variant B.220.127.116.11 detected in India by NIV
- The variant was remoted from nasal/ throat swabs from worldwide travellers from the UK and Brazil
- The pathogenicity of the isolate was assessed in Syrian hamster mannequin and in contrast with B.1 variant
- The examine was carried out in Vero CCL81 cells and genomic characterisation by next-generation sequencing
New Delhi: A brand new variant of coronavirus B.18.104.22.168 has been detected in India by way of genome sequencing carried out by the Nationwide Institute of Virology, Pune. The variant was remoted from nasal and throat swabs from worldwide travellers from Brazil and the UK. The pathogenicity of the isolate was assessed in Syrian hamster mannequin and in contrast with B.1 variant.
The brand new variant induced physique weight reduction, triggered viral replication within the respiratory observe, lung lesions, and extreme lung pathology in contaminated Syrian hamsters compared to D614G variant (B.1).
The check was carried out for about seven days on 9 Syrian hamsters. The study was carried out in Vero CCL81 cells and genomic characterisation by next-generation sequencing.
Consultants opine that the brand new variant is much like the Delta variant and might be extra harmful than the Alpha variant.
The sera from B.22.214.171.124 contaminated hamsters effectively neutralized the D614G variant virus whereas 6-fold discount within the neutralization was seen in case of D614G variant contaminated hamsters’ sera with the B.126.96.36.199.
The examine concluded that the “B.188.8.131.52 lineage variant might be efficiently remoted and characterization might be carried out. Pathogenicity of the isolate was demonstrated in Syrian hamster mannequin and compared, with B.1 variant was discovered extra pathogenic. The findings of elevated illness severity and neutralization discount is of nice concern and level in direction of the necessity for screening the vaccines for efficacy.”
“The B.184.108.40.206 variant which was discovered extra pathogenic in hamsters producing extreme pneumonia compared with B.1 lineage variant. The B.1 variant contaminated hamster sera confirmed lowered neutralization towards B.220.127.116.11. The examine factors in direction of the need of genomic surveillance and characterization of the SARS-CoV-2 variants to grasp its pathogenicity and immune escape potential for preparedness.”